O’Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK. A µ-opioid receptor modulator that works cooperatively with naloxone. Nature. 2024; 631: 686-693.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O’Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Stepwise activation of a metabotropic glutamate receptor. Nature. 2024; 629: 951-956.
Tummino TA, Iliopoulos-Tsoutsouvas C, Braz JM, Krishna Kumar K, O’Brien ES, Stein RM, Craik V, Tran NK, Ganapathy S, Shiimura Y, Tong F, Ho TC, Moroz YS, Liu F, Rosado SR, Bhardwaj K, Benitez J, Liu Y, Kandasamy H, Normand C, Semache M, Sabbagh L, Glenn I, Irwin JJ, Kobilka BK, Makriyannis A, Basbaum AI, Shoichet BK. Large library docking for cannabinoid-1 receptor agonists with reduced side effects. bioRxiv. https://doi.org/10.1101/2023.02.27.530254
Zhao J, Elgeti M, O’Brien ES, Sar C, El Daibani A, Heng J, Sun X, Che T, Hubbell W, Kobilka BK, Chen C. Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature. 2024; 629: 474-480.
Krishna Kumar K,* O’Brien ES*, Habrian C, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK. Negative allosteric modulation of the glucagon receptor by RAMP2. Cell. 2023; 186(7): 1465-77. *Co-first authors
Hilger D, Krishna Kumar K, Hu H, Pedersen MF, O’Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Structural insights into differences in G protein activation by family A and family B GPCRs. Science. 2020; 369(6503): eaba 3373.
O’Brien ES, Fuglestad B, Lessen HJ, Stetz MA, Lin DW, Marques BS, Fleming KG, Wand AJ. Membrane proteins have distinct fast internal motion and residual conformational entropy. Angew Chemie Int Ed. 2020; 59(27): 11108-11114.
O’Brien ES, Lin DW, Fuglestad B, Stetz MA, Gosse T, Tommos C, Wand AJ. Improving yields of deuterated, methyl labeled protein by growing in H2O. J Biomol NMR. 2018; 71(4): 263-273.
O’Brien ES, Sharp KA, Wand AJ. On the ability of molecular dynamics force fields to recapitulate NMR derived protein side chain order parameters. Prot Sci. 2016; 25(6): 1156-60.
O’Brien ES, Nucci NV, Fuglestad B, Tommos C, Wand AJ. Defining the apoptotic trigger: the interaction of cytochrome c and cardiolipin. J Biol Chem. 2015; 290(52): 30879-87.
Harpole KW, O’Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Prot Sci. 2016; 25(2): 423-32.
Sharp KA, O’Brien ES, Kasinath V, Wand AJ. On the relationship between NMR-derived amide order parameters and protein backbone entropy changes. Proteins. 2015; 83(5): 922-30.
Dodevski I, Nucci NV, Valentine KG, Sidhu GK, O’Brien ES, Pardi A, Wand AJ. Optimized reverse micelle surfactant system for high-resolution NMR spectroscopy of encapsulated proteins & nucleic acids dissolved in low-viscosity fluids. J Am Chem Soc. 2014; 136(9): 3465-74.